Dr. Stephen Chan’s JCI publication was highighted in a recent Tribune-Review article featuring PH patient Julia Feitner: “Experts seek origin of pulmonary hypertension to design treatment”.
After she was diagnosed with pulmonary hypertension during a 2008 pregnancy, Julia Feitner feared she would have to make a choice between her baby's life and her own. The disease, which impedes passage of blood from the heart to the lungs, is especially hard on pregnant women, whose hearts need to pump extra blood to nourish their babies.
Bertero T, Oldham WM, Cottrill KA, Pisano S, Vanderpool RR, Yu Q, Zhao J, Tai Y, Tang Y, Zhang YY, Rehman S, Sugahara M, Qi Z, Gorcsan III J, Vargas SO, Saggar R, Saggar R, Wallace WD, Ross DJ, Haley KJ, Waxman AB, Parikh VN, De Marco T, Hsue PY, Morris A, Simon MA, Norris KA, Gaggiol, C, Loscalzo J, Fessel J, Chan SY (Senior Author). Vascular stiffness mechanoactivates YAP/TAZ- dependent glutaminolysis to drive pulmonary hypertension. J Clin Invest. 2016. Sep 1;126(9):3313-35. [PMID 27548520 | PMCID PMC5004943].